Original Research: Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development
نویسندگان
چکیده
منابع مشابه
Pityriasis rosea-like Drug Eruption Induced by Imatinib Mesylate (Gleevec™)
Imatinib mesylate (Gleevec™, STI571), a selective inhibitor of BCR-ABL, c-Kit, and platelet-derived factor receptor, has been used to treat chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors. Although its use has been associated with various adverse cutaneous reactions, pityriasis rosea-like drug eruptions are rare. Here, we report a case of pityriasis rosea-like drug erupti...
متن کاملHematopathology / IMATINIB MESYLATE (GLEEVEC) FOR CHRONIC MYELOID LEUKEMIA Chronic Myeloid Leukemia Following Therapy With Imatinib Mesylate (Gleevec) Bone Marrow Histopathology and Correlation With Genetic Status
We evaluated bone marrow pathologic features and cytogenetic and molecular genetic status of 13 patients with interferon-resistant, chronic-phase chronic myeloid leukemia (CML), treated with imatinib mesylate (Gleevec). All had morphologic evidence of CML in the blood and bone marrow and were positive for bcr-abl by reverse transcriptase–polymerase chain reaction, fluorescence in situ hybridiza...
متن کاملPotential role of imatinib mesylate (Gleevec, STI-571) in the treatment of vestibular schwannoma.
HYPOTHESIS To determine the expression of the tyrosine kinases platelet-derived growth factor receptor (PDGFR) and c-Kit in vestibular schwannoma (VS) and to determine the potential role of imatinib mesylate (Gleevec) in regulating the growth and cell death of this tumor. BACKGROUND Protein tyrosine kinases are transmembrane tyrosine kinase receptors that transduce signals from inside and out...
متن کاملOriginal Research Article
Anatomical Department University of Medicine and Pharmacy "Victor Babes" Timisoara, Romania ABSTRACT: In this study, a three-dimensional (3-D) model of the pelvis was built based on thin slice plastination cross-sections of the adult female pelvis and 3-D reconstruction technology. A female pelvis was obtained, MRI scanned, plastinated, sectioned and subjected to 3-D computerized reconstruction...
متن کاملOriginal Research Article
Division of Biomedical Sciences (Anatomy) St George's, University of London London, UK ABSTRACT: The standard method for plastination with Biodur TM S10/S3 involves lowtemperature dehydration in a volatile intermediary solvent followed by forced impregnation under vacuum at -15°C. However, some institutions have been reluctant to install low-temperature impregnation equipment because of health ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2016
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370216665175